Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies

Table 1

Pharmacological and procedural recommendations for treatment of knee osteoarthritis.

Society	Recommended	Inconclusive	Not recommended
Arthritis Alliance of Canada/College of Family Physicians of Canada	(i) Topical NSAIDs; (ii) Acetaminophen; (iii) Oral NSAIDs (in patients without contraindications); (iv) SNRI (i.e., duloxetine); (v) Opioids (tramadol is preferred as nontramadol opioids having a higher incident of side effects with small effects on pain); (vi) I-CS	(i) Herbal medications; (ii) I-HA; (iii) I-PRP; (iv) Stem cells	(i) Capsaicin; (ii) Chondritin; (iii) Neuropathic pain modulators; (iv) Glucosamine
American Academy of Orthopedic Surgeons	(i) Topical NSAIDs; (ii) Oral NSAIDs; (iii) Tramadol	(i) Acetaminophen; (ii) Nontramadol opioids; (iii) I-CS; (iv) I-PRP	(i) Chondritin; (ii) Glucosamine; (iii) I-HA
Osteoarthritis Research Society International	(i) Topical NSAIDs; (ii) Capsaicin; (iii) Acetaminophen (in patients without comorbidities); (iv) Oral NSAIDs (in patients without comorbidities); (v) SNRI (i.e., duloxetine in patients without comorbidities); (vi) I-CS	(i) Chondritin (for symptom relief); (ii) Glucosamine (for symptom relief); (iii) Opioids; (iv) I-HA	(i) Chondritin (for disease modification); (ii) Glucosamine (for disease modification)
American College of Rheumatology	(i) Topical NSAIDs; (ii) Acetaminophen; (iii) Oral NSAIDs; (iv) Tramadol; (v) I-CS	(i) SNRIs (i.e., duloxetine); (ii) Nontramadol opioids; (iii) I-HA	(i) Topical capsaicin; (ii) Chondritin; (iii) Glucosamine