Resolution-Free Accurate DNA Contour Length Estimation from Atomic Force Microscopy Images

Figure 3

Illustration of DNA image preprocess to extract contour skeleton backbone. (a) Original AFM image cut-out with a single DNA sample. (b) Binary image acquired by thresholding the original. (c) Skeleton extracted by a repetitive thinning process to produce a single-pixel width, connected contour.

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(b)

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