Bone Marrow-Derived Mesenchymal Stem Cells Repair Necrotic Pancreatic Tissue and Promote Angiogenesis by Secreting Cellular Growth Factors Involved in the SDF-1α/CXCR4 Axis in Rats

Figure 5

The transplanted SPION-labeled BMSCs were tracked by MRI in vivo. (a) [Fe³⁺] was detected by MRI and the result showed that the SPION-labeled BMSCs ([Fe³⁺] = 25 g/mL) appeared high signals (white spots) on T1WI and low signals (dark spots) on T2WI. (b) The SPION-BMSCs ([Fe³⁺] = 25 g/mL) was tracked by MRI in vivo and the photos show that the white spots (inside of red circle) were increasing gradually and peaked on postoperative days 5–7. Instead, the white spots decreased on postoperative day 5 in anti-CXCR4 group compared with BMSCs group. (c) The SPION-BMSCs ([Fe³⁺] = 25 g/mL) were detected in SAP rats at postoperative day 7 by T1WI and T2WI and the result was showing that the high signals (white spots), which appeared in T1WI, became low signals (dark spots) in T2WI (SPION, superparamagnetic iron oxide nanoparticles, T1WI, T1-weighted imaging, and T2WI, T2-weighted imaging).

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