Bone Marrow-Derived Mesenchymal Stem Cells Repair Necrotic Pancreatic Tissue and Promote Angiogenesis by Secreting Cellular Growth Factors Involved in the SDF-1α/CXCR4 Axis in Rats

Figure 8

Transplantation BMSCs could promote angiogenesis in damaged pancreatic tissue, which was inhibited by anti-CXCR4 treatment. ((a), (d)) VEGF expression was assayed in pancreatic tissue by immunohistochemistry and the result showed that VEGF expression was higher in SAP+BMSCs group than in normal, SAP, and anti-CXCR4 groups at postoperative days 1 and 4. On the contrary, it was lower in SAP+BMSCs group than in SAP group at postoperative day 7. ((b)–(d)) vWf and CD31 expressions in pancreatic tissue were showed to be significantly higher in SAP+BMSCs group than in normal, SAP, and SAP+anti-CXCR4 BMSCs groups. Data are expressed as mean ± SD (^# for sham versus NC, and for SAP+BMSCs versus NC, ^†, ^††, and ^††† for SAP+BMSCs versus SAP, , , and for SAP+BMSCs versus SAP+anti-CXCR4 BMSCs at each corresponding time point) (NC, normal control, VEGF, vascular endothelial growth factor, SAP, severe acute pancreatitis, BMSCs, bone marrow-derived mesenchymal stem cells, vWF, von Willebrand factor, and CD31, platelet endothelial cell adhesion molecule-1).

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