Role of HOX Genes in Stem Cell Differentiation and Cancer

Figure 4

HOX gene expression during different stages of CRC. RNA sequencing data for CRC patients obtained from The Cancer Genome Atlas (TCGA) for HOX gene expression (normalized FPKM) and analyzed based on different stages of CRC. We studied (a) 55 cases for stage I, (b) 102 cases for stage IIA and IIB combined, (c) 66 cases reporting stage IIIA, IIIB, and IIIC, (d) 39 samples for stage IV, and (e) 4 cases for stage IVA. (f) Fold changes in the expression of HOXB6 and HOXB8 are shown for stages II, III, IV, and IVA compared to stage I.

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