Role of HOX Genes in Stem Cell Differentiation and Cancer

Figure 8

Correlation analysis of HOX genes and retinoid receptors with stem cell markers in colorectal cancer. (a) The expression of HOXA9 and ALDH1A1 (SC marker) in colorectal cancer (CRC) patients is correlated by Pearson correlation. A positive significant correlation was observed between HOXA9 and ALDH1A1 (, ). (b) The expression of retinoid receptor RXRB and ALDH1A1 in CRC patients is correlated by Pearson correlation. A negative significant correlation was observed between RXRB and ALDH1A1 (, ). (c) The expression of HOXA4 and ALCAM (CD166, SC marker) in CRC patients correlated by Pearson correlation. A negative significant correlation was observed between HOXA4 and ALCAM (, ). (d) The expression of HOXA9 and ALCAM in CRC patients correlated by Pearson correlation. A positive significant correlation was observed between HOXA9 and ALCAM (, ). (e) The expression of HOXD10 and ALCAM in CRC patients correlated by Pearson correlation. A negative significant correlation was observed between HOXD10 and ALCAM (, ). (f) The expression of HOXB8 and ALCAM in CRC patients correlated by Pearson correlation. A positive significant correlation was observed between HOXB8 and ALCAM (, ).

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