Review Article

Using Mesenchymal Stem Cells to Treat Female Infertility: An Update on Female Reproductive Diseases

Table 2

Application of MSC therapy in the treatment of female reproductive dysfunction.

MSC typesDiseaseTreatmentModelMain resultsReferences

Bone marrow stromal cellsOvarian dysfunctionCTX-induced ovarian failureIntravenous injectionRabbitOvarian function ↑31
CTX-induced ovarian failureLocal injectionMiceRestore ovarian hormone production34
Endometrial disorders24-gauge needle-induced ASLabeled with SPIOs local/tail vein injectionMiceEndometrial proliferation ↑41
Refractory ASUterine artery injectionHumanReconstruct the endometrium40

Adipose-derived stem cellsOvarian dysfunctionCisplatin-induced ovarian failureLocal injectionMiceOvarian function ↑49
TG-induced ovarian damageCollagen scaffoldRatFertility ↑51
Endometrial disordersTrichloroacetic acid-induced ASIntraperitoneal injectionRatFibrosis ↓, endometrial proliferation ↑52

MB-MSCsOvarian dysfunctionCTX-induced POFLocal injectionMiceOvarian weight ↑, hormone secretion ↓59
Cisplatin-induced POFLocal injectionMiceOvarian function ↑, fibroblast growth factor 2 ↑62
Endometrial disordersSevere ASDeliver through the cervix to the fundus of the uterusHumanEndometrial thickness ↑70
Mechanical injured-induced intrauterine adhesionLocal injectionRatPregnancy rate ↑77

UC-MSCsOvarian dysfunctionCTX-induced POFTail vein injectionMiceWeight of the ovaries ↑, estradiol ↑,80
Paclitaxel-induced POFLocal injectionRatFollicle-stimulating hormone ↓, estradiol ↑, ovarian function ↑81
Perimenopausal ovaryTail vein injectionRatEstradiol ↑, follicle-stimulating hormone ↓, follicle number ↑85
Busulfan CTX-induced premature ovarian insufficiencyLocal injectionMiceFertility ↑, ovarian functions ↑77
Endometrial disordersUterine nicheLocal intramuscular injectionHumanUterine scar reconstruction ↑, uterine niche incidence ↓91
95% ethanol-induced endometrial injuryTail vein injectionRatFertility ↑, endometrial fibrosis ↓, angiogenesis ↑87

CTX: cyclophosphamide; TG: tripterygium glycosides; ↑: increase; ↓: decrease.