Review Article

Obstructive Sleep Apnoea Syndrome and Weight Loss: Review

Table 2

A summary of studies of surgically induced weight loss in obstructive sleep apnoea.

PaperDesignn% MaleGroupProcedureFollowup monthsΔBMIΔAHI% with OSA cure

Behrens et al., 2011 [65]Retrospective, cohort34 (21 OSA)3BMI > 30LSG1050.3→39.9?76
Martí-Valeri et al., 2007 [81]Cohort30 (14 OSA)90Obese with associated respiratory comorbidity requiring NIPPVRYGB1256→3264→17 (RDI)?
Fritscher et al., 2007 [78]Cohort1275BMI ≥ 35 with obesity-related comorbidity or ≥40 without and AHI ≥ 15RYGB1856→3446→1625
Haines et al., 2007 [69]Prospective, cohort101?Obese, RDI > 5, ESS ≥ 6RYGB1156→3851→15 (RDI)?
Kalra et al., 2005 [66]Retrospective, cohort34 (19 AHI ≥ 5)?Adolescent, BMI ≥ 40, obesity-related comorbidityRYGB560.8→41.69.1→0.6?
Lankford et al., 2005 [70]Retrospective, cohort1540Obese, OSARYGB1248→3240→?0
Guardiano et al., 2003 [71]Retrospective, cohort812Obese, OSARYGB2849→3455→14 (RDI)50
Peiser et al., 1984 [72]Cohort1593Morbidly obese with OSARYGB3?82→1580
Lettieri et al., 2008 [73]Retrospective, cohort2425Obese with EDS, AHI ≥ 5GB1251→3248→244
Rasheid et al., 2003 [74]Prospective, cohort11?Obese, ESS ≥ 6, RDI > 5GB1262→4056→23 (RDI)?
Rao et al., 2009 [63]Retrospective, cohort46?BMI ≥ 32.5 with obesity-related comorbidity or ≥37.5 without and AHI ≥ 15LAGB1345→3038→1378
Dixon et al., 2005 [75]Prospective, cohort2568BMI > 35, AHI > 25LAGB1853→3762→13?
Busetto et al., 2005 [80]Cohort17100BMI > 50, AHI > 20IGB656→4959→1459
Grunstein et al., 2007 [64]Prospective, controlled, nonrandomised302330Female: BMI ≥ 38, male: BMI ≥ 34Various2442→32??
Valencia-Flores et al., 2004 [67]Prospective, cohort2945Morbidly obeseVarious1456→3952→?46
Poitou et al., 2006 [79]Prospective cohort3517BMI > 40, AHI > 10RYGB, LAGB1251→4024→1063
Pillar et al., 1994 [76]Cohort1479Morbidly obese with OSARYGB, VBG445→3340→1143
Charuzi et al., 1992 [77]Cohort47?Morbidly obese with OSARYGB, VBG10?61→840
Omana et al., 2010 [68]Retrospective, cohorts12324ObeseLSG (49)
v
LAGB (74)
15
17
52→?
44→?
?
?
55
25

Abbreviations: ΔAHI: apnoea hypopnoea index before and after intervention, ΔBMI: body mass index before and after intervention, EDS: excessive daytime somnolence, ESS: epworth sleepiness scale, GB: gastric bypass, IGB: intragastric balloon, LAGB: laparoscopic adjustable gastric banding, LSG: laparoscopic sleeve gastrectomy, number, NIPPV: noninvasive positive pressure ventilation, OSA: obstructive sleep apnoea, RDI: respiratory disturbance index, RYGB: roux-en-Y gastric bypass, VBG: vertical banded.