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Abstract and Applied Analysis
Volume 2013 (2013), Article ID 341346, 5 pages
Research Article

On Analytical Methods in Neuroblastoma Detection

1Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain
2Hospital La Fe, Bulevar Sur s/n, 46026 Valencia, Spain

Received 11 September 2013; Accepted 7 October 2013

Academic Editor: Constantin Udriste

Copyright © 2013 R. Martínez-Díaz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Nonlinear dynamics of cancer recurrence are known to be governed by several factors as initial tumour size, number of metastatic sites, or quantity of drug resistant cells. The precise extent and location of tumours are very important factors so quantitative and consistent methods of evaluation are needed to assess reponse to patient therapy. Whole-body -metaiodobenzylguanidine (mIBG) scintigraphy is used as primary medical image modality to detect neuroblastoma tumours due to its high specificity and sensitivity. However, current oncological guidelines are based on qualitative observer-dependent analysis. This fact makes it difficult to compare results of scintigraphies taken at different moments during therapy or at different institutions. In this paper, we review analytical methods used in neuroblastoma detection and propose an observer-independent method to quantitatively analyse a -mIBG scintigraphy.