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Abstract and Applied Analysis
Volume 2014, Article ID 173952, 5 pages
http://dx.doi.org/10.1155/2014/173952
Research Article

Antimicrobial Resistance within Host: A Population Dynamics View

1Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
2Chongqing Research Center for Information and Automation Technology, Chongqing Academy of Science & Technology, Chongqing 401123, China

Received 27 December 2013; Accepted 19 January 2014; Published 23 February 2014

Academic Editor: Weiming Wang

Copyright © 2014 Chunji Huang and Aijun Fan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To study the relationship between antimicrobial resistance and the concentration of antibiotics, a competitive population dynamical model is proposed between the susceptible strain and the resistant strain with antibiotic exposure. The strict mathematical analysis is performed, and the results indicate that long-term high strength antibiotic treatment and prevention can induce the extinction of susceptible strain. Thus, the prescribed dose of antibiotics must be strictly controlled during the treatment and prevention of the infections in clinics.