The half saturation constant of the proliferation process
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The effectiveness of RTIs ( = 0 means the therapy is totally ineffective, while = 1 indicates the therapy is effective and the cell-to-cell infection is completely stopped)
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The effectiveness of PIs ( = 1 meaning the therapy with PIs is 100% effective and no newly infectious virus particles will be produced [42])
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The stimulation of T-cell to proliferate in the presence of virus [43]