A Computational Study of HSV-2 with Poor Treatment Adherence

<div>Simulations of model system (<a href="https://static.hindawi.com/articles/aaa/volume-2015/850670/figures/#EEq2">5</a>) showing the contour plots of <svg height="11.7574pt" id="M297" style="vertical-align:-3.16066pt" version="1.1" viewbox="-0.0498162 -8.59674 17.2805 11.7574" width="17.2805pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M636 22C611 29 589 38 560 74C536 104 518 134 495 173L430 300C518 328 592 392 592 492C592 555 563 594 528 618C491 643 435 650 377 650H140L131 618C222 610 223 601 208 518L137 136C121 43 116 40 27 32L18 0H295L300 32C212 40 206 42 223 138L248 279H296C334 279 350 272 369 230C393 174 413 140 441 94C482 24 523 1 626 -8L636 22ZM497 480C497 422 468 374 417 343C387 324 353 315 304 315H255L298 556C303 583 309 598 319 603C331 610 348 613 367 613C448 613 497 573 497 480Z" id="g50-83"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="654" vert-adv-y="654"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,8.203,3.001)"><path d="M490 97L476 124C442 96 405 70 398 70C392 70 390 78 396 114C419 243 448 379 463 432L457 436C446 436 431 439 418 442C393 447 368 451 343 451C281 451 204 418 155 381C74 320 24 206 24 107C24 23 59 -12 88 -12C118 -12 155 5 191 34C236 70 290 122 328 177H330L312 84C296 0 311 -12 331 -12C355 -12 425 24 490 97ZM374 387C371 367 360 299 347 264C323 202 187 53 142 53C128 53 113 73 113 120C113 224 157 332 221 380C241 395 274 403 303 403C330 403 360 395 374 387Z" id="g50-98"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="514" vert-adv-y="514"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,12.882,3.001)"><path d="M387 400C387 425 348 451 303 451C247 451 176 414 132 376C69 322 24 228 24 148C24 43 74 -12 147 -12C211 -12 301 33 363 103L346 128C319 99 249 51 193 51C148 51 112 84 112 165C112 230 130 287 154 330C170 359 199 400 243 400C277 400 304 383 326 354C333 345 343 343 354 348C378 360 387 382 387 400Z" id="g50-100"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="411" vert-adv-y="411"></glyph.data></g></svg> as a function of the modification parameter <svg height="12.6917pt" id="M298" style="vertical-align:-3.40337pt" version="1.1" viewbox="-0.0498162 -9.28833 15.993 12.6917" width="15.993pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M309 -142C211 -61 151 99 151 271S210 601 309 683L288 710C141 611 75 451 75 272V271C75 90 141 -72 288 -169L309 -142Z" id="g50-41"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="358" vert-adv-y="358"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,4.654,0)"><path d="M478 400C478 445 461 451 447 451C425 451 399 442 369 425C316 395 241 339 172 252H170L191 340C198 371 203 395 203 412C203 439 194 451 178 451C147 451 81 411 24 351L43 324C68 349 101 371 111 371C117 371 122 363 115 334L35 -4L42 -11C61 -4 87 3 117 9C130 72 144 130 158 181C241 296 342 379 383 379C398 379 404 370 384 285L330 60C302 -58 282 -164 282 -190S323 -257 354 -257L361 -243C357 -223 359 -177 382 -73L464 303C474 347 478 378 478 400Z" id="g50-229"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="502" vert-adv-y="502"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,11.181,0)"><path d="M283 271C283 451 220 610 70 710L48 683C146 603 207 443 207 271S149 -59 48 -142L70 -169C220 -67 283 90 283 271Z" id="g50-42"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="358" vert-adv-y="358"></glyph.data></g></svg> and the proportion of individuals who are adhering to the HSV-2 antiviral treatment <svg height="11.4781pt" id="M299" style="vertical-align:-2.18977pt" version="1.1" viewbox="-0.0498162 -9.28833 16.0452 11.4781" width="16.0452pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M309 -142C211 -61 151 99 151 271S210 601 309 683L288 710C141 611 75 451 75 272V271C75 90 141 -72 288 -169L309 -142Z" id="g50-41"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="358" vert-adv-y="358"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,4.654,0)"><path d="M482 498C482 606 448 710 328 710C138 710 24 416 24 218C24 99 58 -12 184 -12C373 -12 482 294 482 498ZM395 521C395 483 391 449 383 395H128C158 537 226 671 312 671C388 671 395 566 395 521ZM375 342C348 190 284 25 192 25C128 25 109 116 109 199C109 243 112 292 121 342H375Z" id="g50-230"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="506" vert-adv-y="506"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,11.233,0)"><path d="M283 271C283 451 220 610 70 710L48 683C146 603 207 443 207 271S149 -59 48 -142L70 -169C220 -67 283 90 283 271Z" id="g50-42"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="358" vert-adv-y="358"></glyph.data></g></svg>.</div>

Abstract and Applied Analysis

A Computational Study of HSV-2 with Poor Treatment Adherence

Figure 3