The Application of Genomic Technologies to Investigate the Inheritance of Economically Important Traits in Goats

Table 3

Hereditary diseases in goats where causal mutations have been identified (Online Mendelian Inheritance Database in Animals, http://omia.angis.org.au/home/).

Disease	Gene	Causal mutation	Reference
-mannosidosis	MANBA	1398delG, leads to frame shift and premature stop codon	Leipprandt et al. (1996) [117]
Goiter	TG	C to G substitution that produces a stop codon at position 296	Veenboer and de Vijlder (1993) [118]
Mucopolysaccharidosis IIID	GNS	Nonsense mutation in codon 102	Cavanagh et al. (1995) [119]
Myotonia	CLCN1	Ala to Pro substitution at 885	Beck et al. (1996) [120]