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Applied Bionics and Biomechanics
Volume 4, Issue 1, Pages 9-17
http://dx.doi.org/10.1080/11762320701403906

A Potential Application of a Piezoelectric Atomiser for Ophthalmic Drug Delivery

Wei Xia,1 Hung-Yao Hsu,1 Lingxue Kong,1 Allan Evans,2 and Ryan Lee3

1Centre for Material and Fibre Innovation, Deakin University, Australia
2Division of Health Sciences, University of South Australia, Adelaide, Australia
3Sunnytec Electronics Co., Ltd., Taiwan

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A liquid atomiser composed of a piezoelectric transducer and a metal plate with numerous micro-apertures is studied to identify the most influential factors on its atomising performance. The Taguchi method is employed in the experiment design and analysis of the study on how each factor acts in the atomising process. An optimal condition is determined for producing a stream of droplets. The study shows that the droplet size and the spraying velocity are suitable for ophthalmic drug delivery application, with an even distribution of the drug over most of the eyeball surface area due to the controllable cross-sectional area of the droplet stream. This greatly improves the treatment effectiveness and efficiency of eye therapy. Finally, a structure of the ophthalmic drug delivery system is proposed.