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Applied Bionics and Biomechanics
Volume 2017, Article ID 7201769, 10 pages
Research Article

Elastic Modulus of Osteoporotic Mouse Femur Based on Femoral Head Compression Test

1Department of Biomedical Engineering, Yonsei University, 1 Yeonsedae-gil, Heungeop-myeon, Wonju-si, Gangwon-do 26493, Republic of Korea
2Power & Ceramic Division, Korea Institute of Materials Science (KIMS), 797 Changwon-daero, Seongsan-gu, Changwon-si, Gyeongsangnam-do 51508, Republic of Korea
3Biomedical System & Technology Group, Korea Institute of Industrial Technology (KITECH), 89 Yangdaegiro-gil, Ipjang-myeon, Seobuk-gu, Cheonan-si, Chungcheongnam-do 31056, Republic of Korea

Correspondence should be addressed to Han Sung Kim; and Cheolwoong Ko;

Received 16 June 2017; Accepted 9 October 2017; Published 10 December 2017

Academic Editor: Luis Gracia

Copyright © 2017 Chang-soo Chon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A biomechanical test is a good evaluation method that describes the structural, functional, and pathological differences in the bones, such as osteoporosis and fracture. The tensile test, compression test, and bending test are generally performed to evaluate the elastic modulus of the bone using mice. In particular, the femoral head compression test is mainly used for verifying the osteoporosis change of the femoral neck. This study conducted bone mineral density analysis using in vivo microcomputed tomography (micro-CT) to observe changes in osteoporosis over time. It proposed a method of identifying the elastic modulus of the femur in the normal group (CON group) and the osteoporotic group (OVX group) through finite element analysis based on the femoral head compression test and also conducted a comparative analysis of the results. Through the femoral head compression test, it was verified that the CON group’s ultimate and yield loads were significantly higher than those of the OVX group. It was considered that this result was caused by the fact that the bone mineral density change by osteoporosis occurred in the proximal end more often than in the femur diaphysis. However, the elastic modulus derived from the finite element analysis showed no significant difference between the two groups.