Review Article

Feasibility of Muscle Synergy Outcomes in Clinics, Robotics, and Sports: A Systematic Review

Table 6

Selected upper limb functionality studies using muscle synergies.

ReferencePathologyAimSubjectsTasksMuscles (segments)Outcomes

[26] Tang et al. 2017Cerebral palsyAssess the upper limb motor dysfunction14 patients
10 healthy children
Reaching tasks10 (trunk and upper limb)(i) Reduced synergies in patients
(ii) Greater synergy variability in patients
[36] Cheung et al. 2012StrokeAssess the upper limb motor dysfunction31 patientsReaching tasks17 (upper limbs)(i) Reduced synergies in affected arm
(ii) Muscle synergies as marker for physiological evaluation
[37] Lee et al. 2013StrokeAssess the ability to modulate muscle coordination14 patients
4 healthy subjects
Isometric tasks9 (upper limb)(i) Correlation with clinical scores
(ii) Muscle synergy vectors as index for pathology severity
[38] Roh et al. 2013StrokeAssess the upper limb motor dysfunction10 patients
6 healthy subjects
Isometric tasks8 (upper limb)(i) Different muscle synergy organization for shoulder muscle
[39] Tropea et al. 2013StrokeAssess changes in motor control after neurorehabilitation6 patients
10 healthy subjects
Reaching task10 (upper limb)(i) Different muscle synergy organization for shoulder muscle
(ii) No difference on muscle synergy organization after rehabilitation
[40] Garcia-Cossio et al. 2014StrokeCharacterize motor control33 patientsMovements of arm and hand8 (upper limb)(i) Correlation between muscle synergies and hand movement functionality
[41] Roh et al. 2015StrokeAssess the upper limb motor dysfunction16 patients
10 healthy subjects
Isometric tasks8 (upper limb)(i) Four synergies in both groups
(ii) Different muscle synergy organization for shoulder muscle
[42] Hesam-Shariati et al. 2017StrokeUse synergies as severity index24 patientsWii-Baseball game6 (upper limb)(i) Reduced synergies in patients with high pathology severity
[43] Godlove et al. 2016StrokeAssess changes in motor control1 patientReaching tasks8 (upper limb)(i) Abnormal muscle synergy organization and cortical activation in the stroke patient
[44] Li et al. 2017StrokeDefine metrics for assessing motor functions10 patients
9 healthy subjects
Reaching tasks7 (upper limb)(i) Different muscle synergy organization in patients
[45] Zariffa et al. 2012Spinal cord injuryExamine change in motor control8 patients
10 healthy subjects
Gripping tasks8 (hand)(i) Different synergies in patients
(ii) No correlation with motor ability
[46] Lunardini et al. 2017DystoniaExamine change in motor control9 patients
9 healthy children
Writing tasks8 (upper limb)(i) Similar muscle synergy organization between groups
[47] Gizzi et al. 2015PainExamine change in neck motor control8 healthy subjects with pain inducedReaching tasks12 (trunk and neck)(i) Different synergy organization with and without induced pain
[48] Muceli et al. 2014PainExamine change in motor control8 healthy subjects with pain inducedReaching tasks12 (upper limb)(i) Higher variability of muscle synergy organization with pain
[49] Heales et al. 2016Lateral epicondylalgiaExamine change in coordination of forearm20 patients
14 healthy patients
Gripping tasks6 (upper limb)(i) Two synergies in both groups
(ii) Different muscle synergy organization between groups
[50] Manickaraj et al. 2017Lateral epicondylalgiaExamine change in motor coordination11 patients
11 healthy subjects
Gripping tasks6 (hand)(i) Reduced synergies in patients
(ii) Use of muscle synergies as index to monitor pain