[Retracted] A Novel Prognostic Stratified System Based on Tumor Budding and the Cell Nest Size in Ureter Urothelial Carcinoma

Table 2

Multivariate analysis for overall survival, disease-specific survival, and disease-free survival in ureter urothelial carcinoma.

	OS		DSS		DFS
	HR (95% CI)		HR (95% CI)		HR (95% CI)
Age	3.669 (1.631-8.254)	0.002	—	—	—	—
LVI	2.340 (0.943-5.805)	0.067	3.298 (1.099-9.893)	0.033	1.215 (0.547-2.696)	0.633
PNI	1.461 (0.610-3.502)	0.395	1.017 (0.363-2.847)	0.975	4.851 (2.130-11.047)	<0.001
Tumor budding^a,b		0.467		0.179		0.900
Tumor budding (1)	1.632 (0.436-6.101)	0.467	3.508 (0.562-21.900)	0.179	1.070 (0.371-3.085)	0.900
Cell nest size^a,b		0.598		0.527		0.310
Cell nest size (1)	0.965 (0.294-3.165)	0.953	0.342 (0.032-3.678)	0.376	0.515 (0.105-2.516)	0.412
Cell nest size (2)	0.438 (0.088-2.169)	0.312	0.485 (0.059-3.977)	0.500	4.763 (0.458-.49.487)	0.191
TBNS grade		0.238		0.045		0.007
TBNS grade (1)	2.925 (0.565-15.314)	0.201	0.939 (0.059-14.946)	0.964	0.547 (0.041-7.284)	0.648
TBNS grade(2)	3.810 (0.637-22.797)	0.143	11.498 (1.500-88.117)	0.019	10.492 (2.296-47.948)	0.002
pT^a,b		0.004		0.002		0.149
pT (1)	7.891 (0.523-118.971)	0.136	88.641 (4.107-1913.212)	0.004	19.818 (0.986-398.287)	0.051
pT (2)	0.301 (0.032-2.811)	0.292	0.899 (0.069-11.680)	0.935	3.447 (0.467-25.459)	0.225
Stage		<0.001		<0.001		0.099
Stage (1)	0.074 (0.003-1.919)	0.117	0.014 (0.000-0.994)	0.050	0.043 (0.001-1.344)	0.073
Stage (2)	3.136 (0.229-42.902)	0.392	4.147 (0.139-123.700)	0.412	0.558 (0.049-6.406)	0.640
Stage (3)	27.904 (1.850-420.920)	0.016	158.695 (3.904-6450.986)	0.007	1.014 (0.087-11.819)	0.991

^aReduction of degrees of freedom due to constants or linearly dependent covariates. ^bConstant or linearly dependent covariable pT; (3): stage (1) + stage (2) + stage (3)-pT (1)-pT (2); cell nest size (3) = TBNS grade (1) + TBNS grade (2)-cell nest size (2); tumor budding (2) = TBNS grade (2).