Finding Biomarker Signatures in Pooled Sample Designs: A Simulation Framework for Methodological Comparisons
Figure 2
Prediction errors for the first scenario: Ten differentially expressed genes with noise levels of variance (a) and (b). On the -axis the five statistical methods SVML, SVMR, RF, PPLS-DA and LDA after -test are shown and on the -axis the prediction error is given. The height of a bar specifies the average prediction error of 500 runs for a specific pool size and the bootstrap confidence intervals are shown. The four bars for a method represent the different sizes of pools (single samples), and which are indicated by the numbers below the bars.
