Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction: Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides

Figure 3

Binding affinities of CD4 peptides. Relative affinities (hCD4-M = 1) to HIV-1 gp120 of peptides mimicking the putative gp120-binding site of human (hCD4-M) and murine CD4 (mCD4-M), as well as peptide variants in which the hot spot residues were replaced by alanine (hCD4-M* and mCD4-M*, resp.), and a cyclized mCD4 mimetic peptide (mCD4-M**, see Table 2 for peptide sequences).