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Advances in Bioinformatics
Volume 2011, Article ID 736593, 12 pages
Research Article

Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction: Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides

1Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Fahrstraße 17, 91054 Erlangen, Germany
2Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Schuhstraße 19, 91052 Erlangen, Germany

Received 30 August 2011; Revised 7 November 2011; Accepted 23 November 2011

Academic Editor: Allegra Via

Copyright © 2011 Kristin Kassler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The Supplementary Material inclues the following figures and tables:

Figure S1 shows two alternative sequence alignments of murine CD4 with human CD4.

Figure S2 illustrates QMEAN scores and QMEAN Z-scores of the two models mCD4-model 1 and mCD4-model 2.

Figure S3 provides information about model evaluation by ProSA.

Table S1 sums-up all values of model evaluation for the two murine CD4 models (mCD4-model 1 and 2).

  1. Supplementary Material