Analytical Cellular Pathology

Analytical Cellular Pathology / 1997 / Article

Open Access

Volume 14 |Article ID 591251 |

Karin Nylander, Elsy‐Britt Schildt, Mikael Eriksson, Göran Roos, "PCNA, Ki-67, p53, bcl-2 and Prognosis in Intraoral Squamous Cell Carcinoma of the Head and Neck", Analytical Cellular Pathology, vol. 14, Article ID 591251, 10 pages, 1997.

PCNA, Ki-67, p53, bcl-2 and Prognosis in Intraoral Squamous Cell Carcinoma of the Head and Neck

Received16 Jan 1997
Revised03 Apr 1997


Eighty patients with primary intraoral squamous cell carcinomas of the head and neck, with a follow‐up of 4–14 years were analysed for clinical outcome in relation to immunohistochemical expression of PCNA, Ki‐67, p53, bcl‐2 and presence of mutations in the p53 gene. The tumour site was not associated with the different parameters calculated. PCNA and Ki‐67 labelling showed median values of 56% and 32%, respectively, and neither antigen was of predictive value. Fiftyfive percent of the tumours expressed p53, and 38 (48%) had mutations in the p53 gene. No association between the presence of p53 protein or mutations in the p53 gene and clinical outcome was found. Bcl‐2 positivity was detected in a minor fraction (10%) of the tumours.

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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