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Analytical Cellular Pathology
Volume 25, Issue 2, Pages 89-93
http://dx.doi.org/10.1155/2003/803192

Gain in 1q is a Common Abnormality in Phyllodes Tumours of the Breast

Kowan J. Jee,1 Gyungyub Gong,2 Sei Hyun Ahn,3 Jeong Mi Park,4 and Sakari Knuutila1

1Departments of Pathology and Medical Genetics, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
2Department of Pathology, University of Ulsan, College of Medicine, ASAN Medical Center, Seoul, South Korea
3Department of General Surgery, University of Ulsan, College of Medicine, ASAN Medical Center, Seoul, South Korea
4Department of Diagnostic Radiology, University of Ulsan, College of Medicine, ASAN Medical Center, Seoul, South Korea

Received 1 May 2002; Accepted 1 December 2002

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We studied DNA copy number changes by CGH and allelic imbalance (AI) on 3p by LOH analysis on 22 phyllodes tumours (PT) of the breast in order to gain insight into the genetic basis of tumour progression in PT. Copy number changes were observed in 14 cases (63%). Gain in 1q with 1q21–23 as the minimal overlapping area was seen in 12 cases (55%). The gain was observed both in benign and malignant tumours. Our study did not reveal any DNA copy number changes or allelic loss on 3p. The results suggest that DNA copy number changes are not associated with the histological grade or clinical behaviour of PT and the chromosomal changes on 3p appear to be rare. Colour figure can be viewed on http://www.esacp.org/acp/2003/25‐2/jee.htm.