Analytical Cellular Pathology

Analytical Cellular Pathology / 2007 / Article

Review | Open Access

Volume 29 |Article ID 586139 |

Isabel López de Silanes, María Paz Quesada, Manel Esteller, "Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer", Analytical Cellular Pathology, vol. 29, Article ID 586139, 17 pages, 2007.

Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer


The messenger RNA 3′-untranslated region (3′UTR) is emerging as critically important in regulating gene expression at posttranscriptional levels. The 3′UTR governs gene expression via orchestrated interactions between mRNA structural components (cis-elements) and specific trans-acting factors (RNA-binding proteins and non-coding RNAs). Alterations in any of these components can lead to disease. Here, we review the mutations in 3′UTR regulatory sequences as well as the aberrant levels, subcellular localization, and posttranslational modifications of trans-acting factors that can promote or enhance the malignant phenotype of cancer cells. A thorough understanding of these alterations and their impact upon 3′UTR-directed posttranscriptional gene regulation will uncover promising new targets for therapeutic intervention.

Copyright © 2007 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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