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Analytical Cellular Pathology
Volume 35, Issue 3, Pages 145-163
Review Article

Modern Trends in Imaging VI: Raman Scattering in Pathology

Zachary J. Smith,1 Thomas R. Huser,1,2 and Sebastian Wachsmann-Hogiu1,3

1Center for Biophotonic Science and Technology, University of California, Davis, CA, USA
2Department of Internal Medicine, University of California, Davis, CA, USA
3Department of Pathology, University of California, Davis, CA, USA

Copyright © 2012 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Raman scattering is the inelastic scattering of light by chemical bonds, and can therefore show molecular specificity. It can be used both in pure spectroscopy mode, and in imaging mode. While many applications of Raman spectroscopy and imaging in the biomedical field have been so far demonstrated, the use of this technology for pathology applications is still in early stages. In this paper we review some of the most important recent developments in this field, including a description of relevant technologies, applications to molecular sensing, characterization of cells and tissues of interest, and disease detection via Raman scattering.