Analytical Cellular Pathology

Analytical Cellular Pathology / 2012 / Article

Open Access

Volume 35 |Article ID 294358 |

Jason Hipp, James Monaco, L. Priya Kunju, Jerome Cheng, Yukako Yagi, Jaime Rodriguez-Canales, Michael R. Emmert-Buck, Stephen Hewitt, Michael D. Feldman, John E. Tomaszewski, Mehmet Toner, Ronald G. Tompkins, Thomas Flotte, David Lucas, John R. Gilbertson, Anant Madabhushi, Ulysses Balis, "Integration of Architectural and Cytologic Driven Image Algorithms for Prostate Adenocarcinoma Identification", Analytical Cellular Pathology, vol. 35, Article ID 294358, 15 pages, 2012.

Integration of Architectural and Cytologic Driven Image Algorithms for Prostate Adenocarcinoma Identification

Received28 Jul 2011
Accepted06 Feb 2012


Introduction: The advent of digital slides offers new opportunities within the practice of pathology such as the use of image analysis techniques to facilitate computer aided diagnosis (CAD) solutions. Use of CAD holds promise to enable new levels of decision support and allow for additional layers of quality assurance and consistency in rendered diagnoses. However, the development and testing of prostate cancer CAD solutions requires a ground truth map of the cancer to enable the generation of receiver operator characteristic (ROC) curves. This requires a pathologist to annotate, or paint, each of the malignant glands in prostate cancer with an image editor software - a time consuming and exhaustive process.Recently, two CAD algorithms have been described: probabilistic pairwise Markov models (PPMM) and spatially-invariant vector quantization (SIVQ). Briefly, SIVQ operates as a highly sensitive and specific pattern matching algorithm, making it optimal for the identification of any epithelial morphology, whereas PPMM operates as a highly sensitive detector of malignant perturbations in glandular lumenal architecture.Methods: By recapitulating algorithmically how a pathologist reviews prostate tissue sections, we created an algorithmic cascade of PPMM and SIVQ algorithms as previously described by Doyle el al. [1] where PPMM identifies the glands with abnormal lumenal architecture, and this area is then screened by SIVQ to identify the epithelium.Results: The performance of this algorithm cascade was assessed qualitatively (with the use of heatmaps) and quantitatively (with the use of ROC curves) and demonstrates greater performance in the identification of malignant prostatic epithelium.Conclusion: This ability to semi-autonomously paint nearly all the malignant epithelium of prostate cancer has immediate applications to future prostate cancer CAD development as a validated ground truth generator. In addition, such an approach has potential applications as a pre-screening/quality assurance tool.

Copyright © 2012 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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