Observer Performance in the Use of Digital and Optical Microscopy for the Interpretation of Tissue-Based Biomarkers

Table 4

Intermodality agreement (optical versus digital) in the assessment of HER2 with whole slides and TMA using percent correct and category-specific percent correct agreement [95% CI].

Intermodality HER2	Percent correct
Scoring category	Whole slides	TMA
All	58.8 [45.0–72.5]	75.1 [69.1–80.7]
0	55.6 [21.4–85.7]	72.0 [56.9–83.8]
1+	30.1 [9.4–54.4]	52.0 [39.8–63.2]
2+	38.4 [22.4–53.8]	41.9 [28.1–55.1]
3+	54.8 [26.7–79.0]	77.5 [62.6–88.7]