Analytical Cellular Pathology

Analytical Cellular Pathology / 2014 / Article
Special Issue

Meeting Abstracts of The 2nd International Congress of the International Academy of Digital Pathology

View this Special Issue

Meeting Abstract | Open Access

Volume 2014 |Article ID 458954 | https://doi.org/10.1155/2014/458954

Klaus Kayser, Stephan Borkenfeld, Amina Djenouni, Joachim Christian Manning, Herbert Kaltner, Gian Kayser, Hans-Joachim Gabius, "Digital Pathology: How Far Are We from Automated Tissue-Based Diagnosis?", Analytical Cellular Pathology, vol. 2014, Article ID 458954, 2 pages, 2014. https://doi.org/10.1155/2014/458954

Digital Pathology: How Far Are We from Automated Tissue-Based Diagnosis?

Received02 Sep 2014
Accepted02 Sep 2014
Published21 Dec 2014

Background

Tissue based diagnosis (TBD) includes all diagnostic procedures that are performed on human tissue for disease classification and treatment. Its computerized information analysis is called Digital Pathology. Herein we will discuss the present stage of IT tools and the assumed clinical perspectives on medical performance and treatment.

Theory

Basically, TBD investigates the function and structures of biological meaningful individual units, such as macromolecules, genes, nuclei, cells, vessels, and organs. All functions are bound to structures that ensure reliable and effective information and energy exchange. Disturbance of structures induces less effective or complete loss of functions. The complex interactions at molecular biological level (macromolecules) and their continuous reproduction require extensive computations in addition to the sophisticated biochemical analysis systems. Nearly all assessable information is of visual nature or can be visualized. Thus, image content analysis applied in a sophisticated manner might be one key procedure to assist human image interpretation or to even replace it.

Image content information includes information that can be derived from predefined functional units (objects), their spatial arrangement (structure), pixel derived features prior of after image transformations (texture), and syntactic compositions of objects or of pixel based primitives (syntactic structure analysis). Statistically significant clusters can represent either new biological significant units (e.g., tubular arrangement of specific (endothelial) cells forming a vessel, spatial composition of cells of different nature (cellular sociology) forming a bronchus with assumed participation of endogenous lectins [1]) or other new items such as entropy flow charts and diffusion densities. All these parameters form a powerful set of image information features. They can be considered to be independent from each other and calculated independently for their specific clinical significance (disease association).

Present Status

The development of whole slide image scanners, their implementation into laboratory and hospital information systems, and development of internet based open access image measurement systems permit the construction of automated disease classifiers with inbuilt image quality control and monitoring. The prerequisites include image standardization (of gray value range, distribution, magnification in relation to object measurements, etc.), detection of regions of interest (ROI), standardized image transformation procedures, and sophisticated statistical algorithms of flexible and self-learning classifiers.

Perspectives

No technical constraint seems to exist that would prohibit a self learning automated disease detection system based upon TBD. Individual bricks are already available, and have been tested in still crude but promising trials. Internet test forums such as EAMUSTM or the recently created Virtual International Pathology Institute (VIPI, http://www.diagnomx.eu/vipi/) can be considered to be milestones in developing IT support in TBD and surgical pathology. The pathologist and the medical community can decide about velocity and support, not about <yes> or <no>.

Acknowledgment

The financial support of the Verein zur Förderung des Biologisch-Technologischen Fortschritts in der Medizin e.V. is gratefully acknowledged.

References

  1. H. Kaltner and H.-J. Gabius, “A toolbox of lectins for translating the sugar code: the galectin network in phylogenesis and tumors,” Histology and Histopathology, vol. 27, no. 4, pp. 397–416, 2012. View at: Google Scholar

Copyright © 2014 Klaus Kayser et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


More related articles

 PDF Download Citation Citation
 Download other formatsMore
 Order printed copiesOrder
Views1499
Downloads548
Citations

Related articles

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.