Analytical Cellular Pathology

Research Article

Nonalcoholic Fatty Liver Disease: Different Classifications Concordance and Relationship between Degrees of Morphological Features and Spectrum of the Disease

Table 1

Degree of morphological features and fibrosis stage in NASH and non-NASH biopsies according to Bedossa’s histological algorithm.
Morphological featuresNAFDL value
NASHNon-NASH
Steatosis   < 0.001
 5–33%12 (27.27%)22 (81.48%) 
 33–66%21 (47.73%)5 (18.52%) 
 >66%11 (25%)0 
Ballooning   < 0.001
 Absent014 (51.85%) 
 Few29 (65.91%)12 (44.44%) 
 Frequent15 (34.09%)1 (3.71%) 
Lobular inflammation   < 0.001
 Absent021 (77.78%) 
 <2 foci/field28 (63.63%)6 (22.22%) 
 2–4 foci/field16 (36.37%)0 
Fibrosis   < 0.001
 Absent11 (25%)12 (44.5%) 
 Perisinusoidal or periportal12 (27.3%)14 (51.8%) 
 Perisinusoidal and periportal12 (27.3%)1 (3.7%) 
 Bridging fibrosis6 (13.6%)0 
 Cirrhosis3 (6.8%)0 
Total44 (61.98%)27 (38.02%) 
NAFLD: nonalcoholic fatty liver disease; NASH: nonalcoholic steatohepatitis.