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Analytical Cellular Pathology
Volume 2014, Article ID 767215, 6 pages
Research Article

A Comparative and Evaluative Study of Two Cytological Grading Systems in Breast Carcinoma with Histological Grading: An Important Prognostic Factor

1Department of Pathology, U. P. Rural Institute of Medical Sciences & Research, Saifai, Etawah 206301, India
2Department of Pharmacology, U. P. Rural Institute of Medical Sciences & Research, Saifai, Etawah 206301, India
3Department of Pathology, RML Institute of Medical Sciences, Lucknow, India
4Department of Pathology, BPS Medical College, Khanpur, Sonepat, Haryana, India

Received 25 August 2014; Accepted 7 November 2014

Copyright © 2014 Pinki Pandey et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Cytonuclear gradings in the breast carcinoma raise the level of FNA reportage and improves patient management. Our aim was to evaluate and compare two cytological grading methods (Robinson’s and Mouriquand’s) in breast carcinoma and correlate it with Nottingham modification of Scarff-Bloom-Richardson (SBR) histological grading. Materials and Methods. 30 cytologically proven cases of infiltrating ductal carcinoma were graded cytologically and histologically. Cytograding was done by Robinson’s and Mouriquand’s methods (grades I to III) followed by comparison of the two methods. Cytogradings were correlated with SBR grading method. Sensitivity, specificity, diagnostic accuracy, and concordance and discordance rates were evaluated. Results. An overall concordance of 76.66% between cytogradings, of 83.33% between Robinson’s method and SBR, and of 66.66% between Mouriquand’s method and SBR was seen. Robinson’s method correlated best with SBR in all the three nuclear grades. Robinson’s method showed a diagnostic accuracy of 90% with 91.30% sensitivity while Mouriquand’s method had an accuracy of 76.66% with 95.65% sensitivity. The specificity by Mouriquand’s method was quite low (14.28%) as compared to Robinson’s method (85.71%). Conclusion. Comprehensive cytological grading of breast cancer by Robinson’s method seems better because of more objective set of criteria, easy reproducibility, and specificity.