Chemoresistance, Cancer Stem Cells, and miRNA Influences: The Case for Neuroblastoma

Table 2

Previous research identifying miRNAs involved in NB pathogenesis and clinical progression.

miRNA	Dysregulated; expression	Target gene	References
miR-17-92	Upregulated	DKK3, CDKN1A,; BIM, and MEF2D ESR1	[22, 89–91]
miR-21	Upregulated	PTEN	[92]
miR-128	Upregulated	NTRK	[93]
miR-380-5p	Upregulated	p53	[94]
miR-558	Upregulated	HPSE	[95]
miR-375	Upregulated	ELAVL4	[96]
let-7	Downregulated	MYCN	[19, 97]
miR-9	Downregulated	MMP-14	[98]
miR-15	Downregulated	BcL2	[99, 100]
miR-103	Downregulated	CDK5R1	[101, 102]
miR-107	Downregulated	CDK5R1	[101, 102]
miR-124	Downregulated	SOX9and PTBP1	[96, 103, 104]
miR-29a	Downregulated	Cdk6 and CDC6	[105]
miR152	Downregulated	DNMT1	[106]
miR-125b	Downregulated	TrkC	[107]
miR-204	Downregulated	BCL2 and NTRK2	[108]
miR-363	Downregulated	ADAM15 and MYO1B	[109]
miR-335	Downregulated	SOX4 and TNC	[109]

Including miR-18a, miR-19a, miR-20a, and miR-92.