Use of miRNAs as Biomarkers in Sepsis

Table 2

miRNAs expression in sepsis.

miRNAs	Expression	Reference(s)
miRNA-150	Some studies report low plasma concentrations in patients with sepsis. However, similar studies reveal no statistically significant differences between patients with and without sepsis. Finally, low levels of miRNA-150 are associated with poor prognosis in critical ill patients	[14, 64]
miRNA-223; miRNA-146a	Downregulating in patients with sepsis	[70, 98]
miRNA-133a	Upregulating in patients with sepsis	[67]
miRNA-181b	Downregulating in patients with sepsis	[9]
miRNA-146a	Upregulating in healthy patients, as opposed to the group of patients with sepsis	[71]
miRNA-16	Upregulating in patients with sepsis	[54, 98]
miRNA-574-5p	Upregulating in patients with sepsis	[99]
miRNA-4772-3p; miRNA-4772-5p; miRNA-4772-5p-iso	Upregulating in patients with sepsis	[73]
miRNA-122	Statistically significant differences regarding the miRNA in patients with sepsis as opposed to the healthy patients	[54]