Quercetin Reduces Ehrlich Tumor-Induced Cancer Pain in Mice

Figure 10

Naloxone did not reverse the effect of quercetin in reducing Ehrlich tumor cells-induced oxidative stress. Mice were treated with quercetin (100 mg/kg, i.p., starting 10 min after tumor administration) during 8 days after the injection of Ehrlich tumor cells (1 × 10⁶ or 1 × 10⁷ cells/25 μL) or saline and, in the 8th day, one group of mice that received quercetin was also treated with naloxone (1 mg/kg i.p. diluted in saline) or its vehicle 1 h before the treatment with quercetin. Three hours after the treatment with quercetin, samples of spinal cord and paw skin were collected for the oxidative stress assays. The FRAP and ABTS ability of spinal cord ((a) and (c), resp.) and paw skin ((b) and (d), resp.) tissues and GSH levels in the spinal cord (e) and paw skin (f) were accessed. Data are presented as means ± SEM of six mice per group per experiment and representative of two separated experiments: compared to the saline group and compared to the tumor group. One-way ANOVA followed by Tukey’s test.

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