Quercetin Reduces Ehrlich Tumor-Induced Cancer Pain in Mice

Figure 2

The chronic treatment with quercetin inhibits in a dose-dependent manner Ehrlich tumor-induced pain-like behavior in mice. Mice received the intraplantar (i.pl.) administration of Ehrlich tumor cells (1 × 10⁶ (a–c) or 1 × 10⁷ (d)) and were treated daily with quercetin (10, 30, and 100 mg/kg i.p.) during 12 days (a–c) or 8 days (d) starting 10 min after tumor injection. The control group of Ehrlich tumor vehicle was saline and saline plus quercetin group was a control of possible per se effects of quercetin. Mechanical hyperalgesia (a), thermal hyperalgesia (b), paw thickness (c), and overt pain-like behavior (d) were evaluated 3 h after the treatment. Data are presented as means ± SEM of six mice per group per experiment and representative of two separated experiments: compared to the saline group and compared to the tumor group. One-way ANOVA followed by Tukey’s test.

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