Quercetin Reduces Ehrlich Tumor-Induced Cancer Pain in Mice

Figure 3

Quercetin does not alter Ehrlich tumor-induced histological modifications. Mice received saline (25 μL) or Ehrlich tumor cells (1 × 10⁶/25 μL) and were treated i.p. with quercetin (100 mg/kg, 2% DMSO diluted in saline) or vehicle (2% DMSO) 10 min after the i.pl. injection. The treatment continued daily during 12 days. In the 12th day, mice were euthanized and the paw was collected for histological analysis performed with hematoxylin/eosin staining. Panel (a) shows the histology of saline i.pl. plus quercetin vehicle group, (b) saline i.pl. plus quercetin (100 mg/kg i.p.), (c and e) tumor animal treated with vehicle, and (d and f) tumor animal treated with quercetin (100 mg/kg i.p.). Arrows indicate intact bone cartilage, presence of skeletal muscle fibers, dermis and epidermis: (a-b) bone/cartilage destruction (c-d), tissue necrosis (e-f), and presence of tumor cells (c–f).

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