Quercetin Reduces Ehrlich Tumor-Induced Cancer Pain in Mice

Figure 5

Quercetin inhibits IL-1β and TNFα production induced by Ehrlich tumor cells in the spinal cord and paw skin. Mice were treated i.p. with quercetin (100 mg/kg, 2% DMSO diluted in saline) or vehicle (2% DMSO) 10 min after the injection of Ehrlich tumor cell (1 × 10⁶/25 μL) or saline (25 μL). The treatment continued daily. In the 12th day after injection, the Ehrlich tumor cells, the spinal cord, and the paw skin samples were collected for cytokine measurement. IL-1β in spinal cord (a) or paw skin (b) and TNFα in spinal cord (c) or paw skin (d) were determined by ELISA. Data are presented as means ± SEM of six mice per group per experiment and representative of two separated experiments: compared to the saline group and compared to the tumor group. One-way ANOVA followed by Tukey’s test.

(a)

(b)

(c)

(d)