Quercetin Reduces Ehrlich Tumor-Induced Cancer Pain in Mice

Figure 9

Naloxone did not reverse the effect of quercetin in reducing Ehrlich tumor cells-induced cytokine production. Mice were treated with quercetin (100 mg/kg, i.p., starting 10 min after tumor administration) during 8 days after the injection of Ehrlich tumor cells (1 × 10⁶ or 1 × 10⁷ cells/25 μL) or saline and, in the 8th day, one group of mice that received quercetin was also treated with naloxone (1 mg/kg i.p. diluted in saline) or its vehicle 1 h before the treatment with quercetin. IL-1β concentration in spinal cord (a) or paw skin (b) and TNFα concentration in spinal cord (c) or paw skin (d) were determined by ELISA 3 h after the treatment with quercetin. Data are presented as means ± SEM of six mice per group per experiment and representative of two separated experiments: compared to the saline group and compared to the tumor group. One-way ANOVA followed by Tukey’s test.

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