Research Article
Comparison of the Manual, Semiautomatic, and Automatic Selection and Leveling of Hot Spots in Whole Slide Images for Ki-67 Quantification in Meningiomas
Figure 4
Two WSIs with an area of quantification inside a hot spot marked by two experts ((a) and (c): red and yellow rectangles) and chosen by the proposed automatic method ((b) and (d): black rectangles) with examples of 3 areas of quantification for each method and for both WSIs with large and small variation in Ki-67 index value calculated as percentage of immunopositive nuclei to the whole number of nuclei in presented area.
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