Comparison of the Manual, Semiautomatic, and Automatic Selection and Leveling of Hot Spots in Whole Slide Images for Ki-67 Quantification in Meningiomas

Table 3

The results of the pairwise agreement analysis of data, without taking into account categorical information produced using Kendall’s tau-b analysis for interobserver variability on the WSI from sets A and B separately: TM means classical expert microscopic review, P1 and P2 mean pathologists, and AU means proposed automatic method.

	TM	P1	P2	AU
A
TM		0.85281 (0.78355 : 0.87879)	0.79221 (0.71429 : 0.82684)	0.68831 (0.60173 : 0.68831)
P1	0.85281 (0.78355 : 0.87619)		0.92208 (0.88745 : 0.93074)	0.81818 (0.76623 : 0.81818)
P2	0.79221 (0.71429 : 0.82684)	0.92208 (0.88745 : 0.93074)		0.80952 (0.75758 : 0.80952)
AU	0.68831 (0.60173 : 0.68831)	0.81818 (0.76623 : 0.81818)	0.80952 (0.75758 : 0.80952)
B
TM		0.67687 (0.65 : 0.70017)	0.58503 (0.55629 : 0.60697)	0.54762 (0.51888 : 0.56871)
P1	0.67687 (0.64966 : 0.70034)		0.86735 (0.85782 : 0.87398)	0.78231 (0.77262 : 0.78912)
P2	0.58503 (0.55629 : 0.60714)	0.86735 (0.85748 : 0.87381)		0.7551 (0.75 : 0.76531)
AU	0.54762 (0.51871 : 0.56871)	0.78231 (0.77228 : 0.78912)	0.7551 (0.75 : 0.76531)