Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis

Table 4

Odds ratios of genotypes and alleles in different subgroups with idiopathic scoliosis (IS).

Subgroup	Genotype, allele	value	OR [95% CI]
General	GG versus CC	0.002	3.5 [1.54–7.98]
	G versus C	0.0006	2.02 [1.35–3.03]
AIS ()	GG versus CC	0.003	3.75 [1.52–9.27]
	G versus C	0.005	2.3 [1.28–4.16]
Familial history of IS ()	GG versus CC	0.007	10.5 [1.33–83.03]
	G versus C	0.002	3.26 [1.52–7.01]
Cobb angle >40° ()	GG versus CC	0.002	4.25 [1.63–11.05]
	G versus C	0.005	2.3 [1.28–4.16]
Males ()	GG versus CC	0.1	7.27 [0.77–68.89]
	G versus C	0.02	3.27 [1.17–9.16]
Females ()	GG versus CC	0.01	3.02 [1.24–7.39]
	G versus C	0.03	1.9 [1.06–3.38]

A value of was considered to be statistically significant. AIS indicates adolescent idiopathic scoliosis; OR: odds ratio; CI: confidence interval.