Research Article
Intratumoral CD3+ T-Lymphocytes Immunoexpression and Its Association with c-Kit, Angiogenesis, and Overall Survival in Malignant Canine Mammary Tumors
Table 2
Association between considered molecular markers groups and overall survival.
|
Molecular markers | | Overall survival Univariate (mean values) | | Overall survival Multivariate (hazard ratio) | |
|
CD3/c-kit | Low CD3/low c-kit | 22 | 699.154 |
0.002 |
— |
NS | Low CD3/high c-kit or high CD3/low c-kit | 35 | 500.809 | High CD3/high c-kit | 23 | 335.083 |
|
CD3/VEGF | Low CD3/low VEGF | 20 | 696.583 |
0.006 |
— |
NS | Low CD3/high VEGF or high CD3/low VEGF | 35 | 524.480 | High CD3/high VEGF | 25 | 383.500 |
|
c-kit/VEGF | Low c-kit/low VEGF | 12 | 663.167 |
<0.0001 |
6.102 |
0.010 | Low c-kit/high VEGF or high c-kit/low VEGF | 26 | 697.143 | High c-kit/high VEGF | 42 | 371.462 |
|
|
, number of samples; , statistical significance; NS, not significant; Cox proportional hazard model: forward stepwise method-likelihood ratio.
|