Low-Dose Ribavirin Treatments Attenuate Neuroinflammatory Activation of BV-2 Cells by Interfering with Inducible Nitric Oxide Synthase

Figure 3

(a) Effect of RBV on LPS triggered production of NO. (b) Representative Western blot of iNOS expression. Graph shows mean iNOS protein abundance (± SEM), from separate determinations, expressed relative to the abundance of β-actin in each lane. Significance inside the graphs (a) and (b): versus control group, versus LPS stimulated group. (c) Panel of immunofluorescence labeling of BV-2 cells against iNOS (green) and counterstained with Hoechst (blue) after 24 h of stimulation with LPS and treatment with RBV. Scale bar for all pictures in panel (c): 50 μm.

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