Low-Dose Ribavirin Treatments Attenuate Neuroinflammatory Activation of BV-2 Cells by Interfering with Inducible Nitric Oxide Synthase
(a) Effect of RBV on LPS triggered production of NO. (b) Representative Western blot of iNOS expression. Graph shows mean iNOS protein abundance (± SEM), from separate determinations, expressed relative to the abundance of β-actin in each lane. Significance inside the graphs (a) and (b): versus control group, versus LPS stimulated group. (c) Panel of immunofluorescence labeling of BV-2 cells against iNOS (green) and counterstained with Hoechst (blue) after 24 h of stimulation with LPS and treatment with RBV. Scale bar for all pictures in panel (c): 50 μm.
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