In Vivo Flow Cytometry of Circulating Tumor-Associated Exosomes

Figure 4

In vivo detection of CTCs and CTPs in tumor-bearing mouse models. (a) PA signal traces for melanoma animal model using B16F10 cells in label-free mode. Insets show typical peak shapes for CTCs and CTPs. (b) PA signal traces for breast cancer model using MDA-MB-231 cells labeled with conjugated gold nanoparticles. Insets show typical narrow peaks from CTPs and wider peaks from CTCs and/or CTP clusters. (c), (d) Images of CTPs in blood collected from melanoma (c) and breast carcinoma (d) tumor-bearing mice using cells with GFP.

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