In Vivo Flow Cytometry of Circulating Tumor-Associated Exosomes

Figure 6

Monitoring of CTPs at early cancer stages. (a), (b), and (c) show histogram analysis of size frequencies during MTLn3 tumor development showing the prevalence of CTPs at day 5 and an increase in relative number of CTCs and clusters for days 15 and 25 (left) and the hypothesis and schematic of an early stage appearance of CTPs over CTCs in blood circulation (right). (d) Typical number of CTP/CTCs in circulation during tumor progression. (e) Proportion of CTPs (squares) and CTCs (circles) over time after tumor inoculation. (f) Proportion of CTPs and CTCs in carcinoma-bearing mouse at 3 days after tumor inoculation.