Photoacoustic Flow Cytometry for Single Sickle Cell Detection In Vitro and In Vivo

Figure 6

In vitro PAFC of sRBCs. (a) PA signal amplitudes from nRBCs of SCD mouse, flowing in a capillary tube at different dilutions showing completely overlapped (1 : 1) and nonoverlapped (1 : 10⁴) signal peaks from individual sRBCs. (b, d) Typical PA signal traces with nonoverlapping peaks from individual nRBCs of a nude mouse (b) and sRBCs of a SCD mouse (d). (c) Averaged PA signal amplitudes from nRBCs and sRBCs in (b, d).