PECAM-1 Leu125Val (rs688) Polymorphism and Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus
Table 1
Clinical and laboratory characteristics of cases and controls.
Cases (DN+)
Controls (DN−)
Sig. ()
Number
276
375
Sex (M)
59.1%
52.4%
0.1
Age (years)
64.75 ± 9.15
63.75 ± 8.0
0.13
Duration of T2D (years)
14.71 ± 7.97
14.60 ± 6.73
0.84
Duration of hypertension (years)
12.23 ± 9.88
10.52 ± 8.22
0.02
SBP [mmHg]
155.27 ± 18.92
149.84 ± 19.63
<0.001
DBP [mmHg]
84.87 ± 11.63
84.06 ± 11.42
0.36
BMI
31.3 ± 4.68
30.77 ± 5.0
0.23
Active smokers
6.6%
8.9%
0.31
CVD
20.0%
12.2%
0.007
Family history of CVD
41.3%
58.7%
0.91
DR
37.8%
24.6%
<0.001
Duration of DR (years)
3.94 ± 3.11
6.54 ± 7.03
0.23
DNeur
9.1%
6.0%
0.38
DF
15.5%
8.1%
0.03
S-HbA1c [%]1
7.98 ± 1.38
7.65 ± 1.14
0.001
S-fasting glucose [mmol/l]
9.03 ± 2.76
8.51 ± 2.53
0.01
S-Hb [g/l]
139.39 ± 14.91
139.40 ± 12.96
0.99
S-urea [mmol/l]
7.35 ± 3.73
6.25 ± 1.91
<0.001
S-creatinine [μmol/l]
93.13 ± 58.21
78.44 ± 20.15
<0.001
Male sex
101.57 ± 61.84
84.28 ± 19.94
<
Female sex
79.7 ± 49.21
71.91 ± 18.35
<0.001
eGFR [MDRD equation, ml/min]
72.6 ± 19.74
75.22 ± 15.16
0.22
male sex
71.97 ± 19.45
77.66 ± 14.33
female sex
74.31 ± 20.72
72.45 ± 15.69
0.13
S-cystatin C [mg/l]
0.95 ± 0.48
0.78 ± 0.21
<0.001
S-Total cholesterol [mmol/l]
4.62 ± 1.17
4.55 ± 0.99
0.42
S-HDL [mmol/l]
1.23 ± 0.35
1.26 ± 0.36
0.29
S-LDL [mmol/l]
2.59 ± 0.95
2.57 ± 0.80
0.73
S-TG [mmol/l]
2.08 ± 1.6
1.83 ± 1.24
0.04
U-albumin/creatinine ratio [g/mol], sample no. 1
27.49 ± 55.46
1.57 ± 3.05
<0.001
U-albumin/creatinine ratio [g/mol], sample no. 2
23.13 ± 39.34
1.60 ± 3.67
<0.001
U-albumin/creatinine ratio [g/mol], sample no. 3
23.36 ± 42.49
1.62 ± 2.49
<0.001
The values represent mean ± standard deviation. Bold indicates statistically significant results. The average value for hemoglobin A1c (HbA1c). Comparing eGFR in men with DN and men without DN. Comparing women with DN and women without DN.
