Annexin A3 Knockdown Suppresses Lung Adenocarcinoma

Figure 4

Downregulating Anxa3 expression inhibited tumor growth and tumor metastasis in vivo. Representative pictures of nude mice (a), tumor nodules (b), the curve of tumor growth (c), and the mean weights (d) of tumor nodules in A549/control and A549/shAnxa3 group were shown. indicates . Immunohistochemical analyses (e) of Anxa3, MMP-2, E-cadherin, N-cadherin, and Ki-67 expression in tissue sections of tumor nodules in the A549/control and A549/shAnxa3 groups were shown. Magnification: ×200. Representative pictures of metastatic tumor nodules in the livers (f) and histograms of metastatic tumor nodules (g) of lung, liver, and brain in the A549/control and A549/shAnxa3 groups were shown. indicates .