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Analytical Cellular Pathology
Volume 2016, Article ID 6074275, 5 pages
http://dx.doi.org/10.1155/2016/6074275
Research Article

VEGF +936 C/T Genetic Polymorphism in Patients with Cervical Dysplasia

11st Clinic of Obstetrics and Gynecology, University of Medicine and Pharmacy “Iuliu Hatieganu”, Clinicilor 3-5, 400006 Cluj-Napoca, Romania
2Department of Economic Sciences, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Manastur 3-5, 400372 Cluj-Napoca, Romania
3Department of Molecular Sciences, University of Medicine and Pharmacy “Iuliu Hatieganu”, Clinicilor 3-5, 400006 Cluj-Napoca, Romania
41st Clinic of Obstetrics and Gynecology, Emergency County Hospital, Cluj-Napoca, Romania

Received 14 June 2016; Accepted 1 September 2016

Academic Editor: Ilary Ruscito

Copyright © 2016 Ioana Cristina Rotar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. The present study aims to analyze the potential role of VEGF +936 C/T polymorphism in cervical intraepithelial neoplasia. Material and Method. One hundred and eighty-six patients were included in the study: 75 cases (patients diagnosed with CIN) and 111 controls (negative for both HPV testing and cytology). For each patient a single visit was scheduled when colposcopy was performed. From cervical specimen, cytology and HPV testing were performed and from peripheral blood VEGF +936 genotyping was determined. For statistical analysis purposes OR and chi-square were used at a level of significance of <0.05. Results. No link has been found in the detection of CT genotype in cases versus controls, OR = 0.8295, [0.42, 1.62]. An inverse correlation has been found between T allele and HSIL, OR = 0.2121, [0.0473, 0.9517], . Conclusion. No link has been found between VEGF +936 C/T and cervical intraepithelial neoplasia.