Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats

Table 2

Effect of kynurenic acid (KYNA) on biochemical parameters in thioacetamide (TAA) induced liver injury in rats.

	Control	KYNA	TAA	KYNA + TAA
KYNA content (pmol/g)	62.6 ± 2.9	239.9 ± 24.3	40.5 ± 2.8	249.5 ± 10.1
AST (U/L)	109.8 ± 7.2	145.3 ± 34.1	316.3 ± 59.3	185.6 ± 17.5^#
ALT (U/L)	54.7 ± 4.6	57.7 ± 5.2	90.2 ± 12.9	57.8 ± 7.8^#
AST/ALT ratio	2.0	2.5	3.5	3.2
–SH groups (mmol/mg protein)	128.8 ± 27.0	108.3 ± 22.0	36.3 ± 10.0	61.5 ± 9.0
MDA + 4HNE (nmol/g)	3.6 ± 0.2	3.6 ± 0.1	4.1 ± 0.2	3.5 ± 0.1^#
MPO (ng/mg protein)	25.4 ± 2.6	31.4 ± 2.3	70.2 ± 2.6	55.5 ± 4.1^#
HO-1 (ng/g)	283.3 ± 11.0	328.9 ± 17.2	349.9 ± 12.2	394.8 ± 11.3
ORAC (TE/mL)	49.0 ± 0.7	48.7 ± 1.1	45.5 ± 0.4	53.0 ± 1.2^#
TNF-α (pg/mL)	22.2 ± 1.7	19.4 ± 1.1	39.1 ± 5.9	27.1 ± 2.1^#
IL-10 (mg/mL)	421.1 ± 43.9	975.6 ± 141.9	576.8 ± 54.5	909.2 ± 49.5

Data represent a mean value ± SEM of 6–8 independent experiments. Statistical analysis was performed using one-way ANOVA with Tukey’s post hoc test; —as compared with control group; —as compared with the TAA group. Control—saline-treated group; KYNA—kynurenic acid- (500 mg/kg) treated group; TAA—thioacetamide- (150 mg/kg) treated group; KYNA + TAA—kynurenic acid (500 mg/kg) and thioacetamide- (150 mg/kg) treated group; AST—aspartate transaminase; ALT—alanine transaminase; –SH groups—thiol groups; MDA + 4HNE—malondialdehyde (MDA) + 4-hydroxynonenal (4-HNE) content; MPO—myeloperoxidase activity; HO-1—heme oxygenase 1 content; ORAC—oxygen radical absorbance capacity; TNF-α—tumor necrosis factor-α; IL-10—interleukin-10.