High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis

Table 3

Expression of PINCH1 in human laryngeal cancer in relation to clinical and pathological parameters.

		PINCH1 cytoplasmic				value	PINCH1 nuclear				value
		Low; (n, %)		High; (n, %)			Low; (n, %)		High; (n, %)
Age	≤60	20	57.1%	15	42.9%	0.036	32	91.4%	3	8.6%	0.508
	>60	12	32.4%	25	67.6%		32	86.5%	5	13.5%
Location	Glottis	18	41.9%	25	58.1%	0.866	38	88.4%	5	11.6%	0.879
	Supraglottis	13	48.1%	14	51.9%		24	88.9%	3	11.1%
	Subglottis	1	50.0%	1	50.0%		2	100.0%	0	0.0%
Grade	Grade I	11	84.6%	2	15.4%	0.003	13	100.0%	0	0.0%	<0.001
	Grade II	19	38.8%	30	61.2%		47	95.9%	2	4.1%
	Grade III	2	20.0%	8	80.0%		4	40.0%	6	60.0%
N	No	29	54.7%	24	45.3%	0.004	48	90.6%	5	9.4%	0.453
	N1–3	3	15.8%	16	84.2%		16	84.2%	3	15.8%
Stage	I	1	100.0%	0	0.0%		1	100.0%	0	0.0%
	II	3	75.0%	1	25.0%		4	100.0%	0	0.0%
	III	17	68.0%	8	32.0%	0.001	24	96.0%	1	4.0%	0.125
	IV	11	26.2%	31	73.8%		35	83.3%	7	16.7%

Statistical analyses were performed by nonparametric tests, and was considered statistically significant. Lymph node (N) metastasis and stage were determined based on TNM, 7th edition [33].