Review Article
Epidermal Growth Factor Receptor Gene in Non-Small-Cell Lung Cancer: The Importance of Promoter Polymorphism Investigation
Table 1
EGFR -191C/A and -216G/T minor allele frequencies in lung cancer patients of different ethnicities.
| | Minor allele frequency | | | SNP | Caucasians | Asians | African Americans | Publication |
| | rs712830 (-191C/A) | 0.136 (6/44) | 0.000 (0/46) | 0.000 (0/48) | Liu et al. [40] | | 0.114 (37/324) | NA | NA | Cusatis et al. [95] | | NA | 0.000 (0/54) | NA | Choi et al. [90] | | 0.071 (13/184) | NA | NA | Liu et al. [15] | | 0.099 (19/192) | NA | NA | Giovannetti et al. [17] | | 0.128 (85/662) | NA | NA | Winther Larsen et al. [78] | | 0.226 (19/84) | NA | NA | Obradović et al. [85] | | NA | 0.035 (9/260) | NA | Bashir et al. [96] |
| | rs712829 (-216G/T) | 0.318 (14/44) | 0.071 (3/46) | 0.292 (14/48) | Liu et al. [40] | | 0.444 (144/324) | NA | NA | Cusatis et al. [95] | | NA | 0.040 (2/54) | NA | Choi et al. [90] | | 0.400 (73/184) | NA | NA | Liu et al. [15] | | 0.440 (144/328) | NA | NA | Gregorc et al. [109] | | 0.401 (77/192) | NA | NA | Giovannetti et al. [17] | | NA | 0.020 (23/1128) | NA | Dong et al. [97] | | NA | 0.050 (14/282) | NA | Liu et al. [98] | | NA | 0.056 (8/142) | NA | Jung et al. [19] | | NA | 0.283 (361/1276) | NA | Guo et al. [99] | | 0.326 (216/662) | NA | NA | Winther Larsen et al. [78] | | NA | 0.130 (60/460) | NA | Zhang et al. [110] | | 0.310 (26/84) | NA | NA | Obradović et al. [85] | | NA | 0.287 (491/856) | NA | Guo et al. [100] | | NA | 0.596 (155/260) | NA | Bashir et al. [96] |
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NA: not available; population mainly Caucasian. |
